Medical History, Lifestyle, Family History, and Occupational Risk Factors for Mantle Cell Lymphoma: The InterLymph Non-Hodgkin Lymphoma Subtypes Project
Identifieur interne : 003730 ( Main/Exploration ); précédent : 003729; suivant : 003731Medical History, Lifestyle, Family History, and Occupational Risk Factors for Mantle Cell Lymphoma: The InterLymph Non-Hodgkin Lymphoma Subtypes Project
Auteurs : Karin E. Smedby ; Joshua N. Sampson ; Jennifer J. Turner ; Susan L. Slager ; Marc Maynadié ; Eve Roman ; Thomas M. Habermann ; Christopher R. Flowers ; Sonja I. Berndt ; Paige M. Bracci ; Henrik Hjalgrim ; Dennis D. Weisenburger ; Lindsay M. MortonSource :
- Journal of the National Cancer Institute. Monographs [ 1052-6773 ] ; 2014.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Amérique du Nord (ethnologie), Amérique du Nord (épidémiologie), Australie (ethnologie), Australie (épidémiologie), Comorbidité, Europe (ethnologie), Europe (épidémiologie), Exposition professionnelle, Facteurs de risque, Femelle, Histoire ancienne, Humains, Jeune adulte, Lymphome à cellules du manteau (diagnostic), Lymphome à cellules du manteau (épidémiologie), Lymphome à cellules du manteau (étiologie), Mode de vie, Stade de la tumeur, Sujet âgé, Sujet âgé de 80 ans ou plus, Études cas-témoins.
- MESH :
- diagnostic : Lymphome à cellules du manteau.
- ethnologie : Amérique du Nord, Australie, Europe.
- épidémiologie : Amérique du Nord, Australie, Europe, Lymphome à cellules du manteau.
- étiologie : Lymphome à cellules du manteau.
- Adulte, Adulte d'âge moyen, Comorbidité, Exposition professionnelle, Facteurs de risque, Femelle, Histoire ancienne, Humains, Jeune adulte, Mode de vie, Stade de la tumeur, Sujet âgé, Sujet âgé de 80 ans ou plus, Études cas-témoins.
- Wicri :
- geographic : Australie.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Australia (epidemiology), Australia (ethnology), Case-Control Studies, Comorbidity, Europe (epidemiology), Europe (ethnology), Female, History, Ancient, Humans, Life Style, Lymphoma, Mantle-Cell (diagnosis), Lymphoma, Mantle-Cell (epidemiology), Lymphoma, Mantle-Cell (etiology), Middle Aged, Neoplasm Staging, North America (epidemiology), North America (ethnology), Occupational Exposure, Risk Factors, Young Adult.
- MESH :
- geographic , epidemiology : Australia, Europe, North America.
- geographic , ethnology : Australia, Europe, North America.
- diagnosis : Lymphoma, Mantle-Cell.
- epidemiology : Lymphoma, Mantle-Cell.
- etiology : Lymphoma, Mantle-Cell.
- Adult, Aged, Aged, 80 and over, Case-Control Studies, Comorbidity, Female, History, Ancient, Humans, Life Style, Middle Aged, Neoplasm Staging, Occupational Exposure, Risk Factors, Young Adult.
Abstract
The etiology of mantle cell lymphoma (MCL), a distinctive subtype accounting for 2%–10% of all non-Hodgkin lymphoma, is not known.
We investigated associations with self-reported medical history, lifestyle, family history, and occupational risk factors in a pooled analysis of 557 patients with MCL and 13766 controls from 13 case–control studies in Europe, North America, and Australia. Odds ratios (ORs) and 95% confidence intervals (CIs) associated with each exposure were examined using multivariate logistic regression models.
The median age of the MCL patients was 62 years and 76% were men. Risk of MCL was inversely associated with history of hay fever (OR = 0.63, 95% CI = 0.48 to 0.82), and the association was independent of other atopic diseases and allergies. A hematological malignancy among first-degree relatives was associated with a twofold increased risk of MCL (OR = 1.99, 95% CI = 1.39 to 2.84), which was stronger in men (OR = 2.21, 95% CI = 1.44 to 3.38) than women (OR = 1.61, 95% CI = 0.82 to 3.19). A modestly increased risk of MCL was also observed in association with ever having lived on a farm (OR = 1.40, 95% CI = 1.03 to 1.90). Unlike some other non-Hodgkin lymphoma subtypes, MCL risk was not statistically significantly associated with autoimmune disorders, tobacco smoking, alcohol intake, body mass index, or ultraviolet radiation.
The novel observations of a possible role for atopy and allergy and farm life in risk of MCL, together with confirmatory evidence of a familial link, suggest a multifactorial etiology of immune-related environmental exposures and genetic susceptibility. These findings provide guidance for future research in MCL etiology.
Url:
DOI: 10.1093/jncimonographs/lgu007
PubMed: 25174028
PubMed Central: 4155462
Affiliations:
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Smedby</name></author><author><name sortKey="Sampson, Joshua N" sort="Sampson, Joshua N" uniqKey="Sampson J" first="Joshua N." last="Sampson">Joshua N. Sampson</name></author><author><name sortKey="Turner, Jennifer J" sort="Turner, Jennifer J" uniqKey="Turner J" first="Jennifer J." last="Turner">Jennifer J. Turner</name></author><author><name sortKey="Slager, Susan L" sort="Slager, Susan L" uniqKey="Slager S" first="Susan L." last="Slager">Susan L. Slager</name></author><author><name sortKey="Maynadie, Marc" sort="Maynadie, Marc" uniqKey="Maynadie M" first="Marc" last="Maynadié">Marc Maynadié</name></author><author><name sortKey="Roman, Eve" sort="Roman, Eve" uniqKey="Roman E" first="Eve" last="Roman">Eve Roman</name></author><author><name sortKey="Habermann, Thomas M" sort="Habermann, Thomas M" uniqKey="Habermann T" first="Thomas M." last="Habermann">Thomas M. Habermann</name></author><author><name sortKey="Flowers, Christopher R" sort="Flowers, Christopher R" uniqKey="Flowers C" first="Christopher R." last="Flowers">Christopher R. Flowers</name></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I." last="Berndt">Sonja I. Berndt</name></author><author><name sortKey="Bracci, Paige M" sort="Bracci, Paige M" uniqKey="Bracci P" first="Paige M." last="Bracci">Paige M. Bracci</name></author><author><name sortKey="Hjalgrim, Henrik" sort="Hjalgrim, Henrik" uniqKey="Hjalgrim H" first="Henrik" last="Hjalgrim">Henrik Hjalgrim</name></author><author><name sortKey="Weisenburger, Dennis D" sort="Weisenburger, Dennis D" uniqKey="Weisenburger D" first="Dennis D." last="Weisenburger">Dennis D. Weisenburger</name></author><author><name sortKey="Morton, Lindsay M" sort="Morton, Lindsay M" uniqKey="Morton L" first="Lindsay M." last="Morton">Lindsay M. Morton</name></author></analytic><series><title level="j">Journal of the National Cancer Institute. Monographs</title><idno type="ISSN">1052-6773</idno><idno type="eISSN">1745-6614</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Australia (epidemiology)</term><term>Australia (ethnology)</term><term>Case-Control Studies</term><term>Comorbidity</term><term>Europe (epidemiology)</term><term>Europe (ethnology)</term><term>Female</term><term>History, Ancient</term><term>Humans</term><term>Life Style</term><term>Lymphoma, Mantle-Cell (diagnosis)</term><term>Lymphoma, Mantle-Cell (epidemiology)</term><term>Lymphoma, Mantle-Cell (etiology)</term><term>Middle Aged</term><term>Neoplasm Staging</term><term>North America (epidemiology)</term><term>North America (ethnology)</term><term>Occupational Exposure</term><term>Risk Factors</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Amérique du Nord (ethnologie)</term><term>Amérique du Nord (épidémiologie)</term><term>Australie (ethnologie)</term><term>Australie (épidémiologie)</term><term>Comorbidité</term><term>Europe (ethnologie)</term><term>Europe (épidémiologie)</term><term>Exposition professionnelle</term><term>Facteurs de risque</term><term>Femelle</term><term>Histoire ancienne</term><term>Humains</term><term>Jeune adulte</term><term>Lymphome à cellules du manteau (diagnostic)</term><term>Lymphome à cellules du manteau (épidémiologie)</term><term>Lymphome à cellules du manteau (étiologie)</term><term>Mode de vie</term><term>Stade de la tumeur</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études cas-témoins</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Australia</term><term>Europe</term><term>North America</term></keywords><keywords scheme="MESH" type="geographic" qualifier="ethnology" xml:lang="en"><term>Australia</term><term>Europe</term><term>North America</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Lymphoma, Mantle-Cell</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Lymphome à cellules du manteau</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Lymphoma, Mantle-Cell</term></keywords><keywords scheme="MESH" qualifier="ethnologie" xml:lang="fr"><term>Amérique du Nord</term><term>Australie</term><term>Europe</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphoma, Mantle-Cell</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Amérique du Nord</term><term>Australie</term><term>Europe</term><term>Lymphome à cellules du manteau</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Lymphome à cellules du manteau</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Case-Control Studies</term><term>Comorbidity</term><term>Female</term><term>History, Ancient</term><term>Humans</term><term>Life Style</term><term>Middle Aged</term><term>Neoplasm Staging</term><term>Occupational Exposure</term><term>Risk Factors</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Comorbidité</term><term>Exposition professionnelle</term><term>Facteurs de risque</term><term>Femelle</term><term>Histoire ancienne</term><term>Humains</term><term>Jeune adulte</term><term>Mode de vie</term><term>Stade de la tumeur</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études cas-témoins</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Australie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>The etiology of mantle cell lymphoma (MCL), a distinctive subtype accounting for 2%–10% of all non-Hodgkin lymphoma, is not known.</p></sec><sec sec-type="methods"><title>Methods</title><p>We investigated associations with self-reported medical history, lifestyle, family history, and occupational risk factors in a pooled analysis of 557 patients with MCL and 13766 controls from 13 case–control studies in Europe, North America, and Australia. Odds ratios (ORs) and 95% confidence intervals (CIs) associated with each exposure were examined using multivariate logistic regression models.</p></sec><sec><title>Results</title><p>The median age of the MCL patients was 62 years and 76% were men. Risk of MCL was inversely associated with history of hay fever (OR = 0.63, 95% CI = 0.48 to 0.82), and the association was independent of other atopic diseases and allergies. A hematological malignancy among first-degree relatives was associated with a twofold increased risk of MCL (OR = 1.99, 95% CI = 1.39 to 2.84), which was stronger in men (OR = 2.21, 95% CI = 1.44 to 3.38) than women (OR = 1.61, 95% CI = 0.82 to 3.19). A modestly increased risk of MCL was also observed in association with ever having lived on a farm (OR = 1.40, 95% CI = 1.03 to 1.90). Unlike some other non-Hodgkin lymphoma subtypes, MCL risk was not statistically significantly associated with autoimmune disorders, tobacco smoking, alcohol intake, body mass index, or ultraviolet radiation.</p></sec><sec><title>Conclusions</title><p>The novel observations of a possible role for atopy and allergy and farm life in risk of MCL, together with confirmatory evidence of a familial link, suggest a multifactorial etiology of immune-related environmental exposures and genetic susceptibility. These findings provide guidance for future research in MCL etiology.</p></sec></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I." last="Berndt">Sonja I. Berndt</name><name sortKey="Bracci, Paige M" sort="Bracci, Paige M" uniqKey="Bracci P" first="Paige M." last="Bracci">Paige M. Bracci</name><name sortKey="Flowers, Christopher R" sort="Flowers, Christopher R" uniqKey="Flowers C" first="Christopher R." last="Flowers">Christopher R. Flowers</name><name sortKey="Habermann, Thomas M" sort="Habermann, Thomas M" uniqKey="Habermann T" first="Thomas M." last="Habermann">Thomas M. Habermann</name><name sortKey="Hjalgrim, Henrik" sort="Hjalgrim, Henrik" uniqKey="Hjalgrim H" first="Henrik" last="Hjalgrim">Henrik Hjalgrim</name><name sortKey="Maynadie, Marc" sort="Maynadie, Marc" uniqKey="Maynadie M" first="Marc" last="Maynadié">Marc Maynadié</name><name sortKey="Morton, Lindsay M" sort="Morton, Lindsay M" uniqKey="Morton L" first="Lindsay M." last="Morton">Lindsay M. Morton</name><name sortKey="Roman, Eve" sort="Roman, Eve" uniqKey="Roman E" first="Eve" last="Roman">Eve Roman</name><name sortKey="Sampson, Joshua N" sort="Sampson, Joshua N" uniqKey="Sampson J" first="Joshua N." last="Sampson">Joshua N. Sampson</name><name sortKey="Slager, Susan L" sort="Slager, Susan L" uniqKey="Slager S" first="Susan L." last="Slager">Susan L. Slager</name><name sortKey="Smedby, Karin E" sort="Smedby, Karin E" uniqKey="Smedby K" first="Karin E." last="Smedby">Karin E. Smedby</name><name sortKey="Turner, Jennifer J" sort="Turner, Jennifer J" uniqKey="Turner J" first="Jennifer J." last="Turner">Jennifer J. Turner</name><name sortKey="Weisenburger, Dennis D" sort="Weisenburger, Dennis D" uniqKey="Weisenburger D" first="Dennis D." last="Weisenburger">Dennis D. Weisenburger</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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